Optimised drug discovery integrated end-to-end

TARGET IDENTIFICATION

VONBIO

Multi-Omics Analysis



To gain insights, preprocess and analyse the big data in human biology

Systems & Network Biology



Use existing or new interaction information and gene expressions to create a knowledge graph.

Target Identification



Analyze Graph Neural Networks to identify, and prioritize biomarkers.

DRUG DESIGN

VONCHEM & VONPRO

QSAR like models



Build QSAR like property models to predict bioactivity, physicochemical or pharmacokinetic properties using Machine Learning and Deep Learning.

Molecule design



Molecules designed to fit the desired chemical space using AI.

Screening



Generated molecules or commercially available molecules are screened virtually as per the hypothesis with multiple layers of screens.

Molecule Optimization



Drug-like molecules optimized with AI flows to improve efficacy, affinity, and selectivity.

SYNTHESIS PLANNING

REVON

Retrosynthetic Analysis



Prediction of synthetic routes by breaking down complex molecules into simpler commercially available reactants.

Chemical Catalogue



Find the links of simpler commercially available starting materials in the synthetic routes with purchases facilitated.

Synthesis



Generate analogues easily with the synthetic paths.

MED CHEM & BIOLOGY CAPABILITIES

Compound Synthesis



Efficient and scalable synthesis of new drug compounds using automated technology.

High throughput binding studies through SPR



binding efficacy analysis of compounds through high throughput surface plasmon resonance (SPR) studies

Validation in Cell-free and Cell-Based mechanistic studies and Cell human disease models



compounds shortlisted through SPR will be validated in cell-free assays and cell-based disease models.

ADME screening



Assessment of Absorption, Distribution, Metabolism, and Excretion (ADME) properties of lead candidates.

In-vitro Tox profiling



Assessment of compound toxicity in relevant cell-based models.

In-vivo efficacy



Evaluation of in-vivo efficacy of the compound in disease-specific animal models.

CLINICAL TRIAL

CLINVON

Patient Simulation



CLINVON works with digital twins, which replicate real-world objects based on previous inputs of data and also deals with generating the sequence of occurrences.

Trial Design



CLINVON simplifies trial design through patient analysis, outcome prediction, criteria development, site selection and recruitment.